Psystrike (Japanese: サイコブレイク Psycho Break) is a damage-dealing Psychic-type move introduced in Generation V. It is the signature move of Mewtwo.
Psystrike inflicts physical damage. Despite being classified as a special move, this move calculates damage using the user's Special Attack and the opponent's Defense stat (similar to Psyshock and Secret Sword).
Despite targeting the opponent's Defense stat, the move's damage is unaffected by Reflect and it will not activate Counter or Shell Trap; instead, it is affected by Light Screen and activates Mirror Coat.
For Mewtwo's Final Smash, it transforms into Mega Mewtwo Y and then uses Psystrike.
In Pokémon GO, Psystrike is a Charged Attack that has been available on September 16, 2019.