Psystrike (Japanese: サイコブレイク Psycho Break) is a damage-dealing Psychic-type move introduced in Generation V. It is the signature move of Mewtwo.
Psystrike inflicts damage. Despite being a special move, Psystrike uses the target's Defense instead of its Special Defense to calculate damage.
Psystrike is still a special move. It uses the user's Special Attack to calculate damage. It activates Mirror Coat (not Counter), has its damage reduced by Light Screen (not Reflect), activates the Maranga Berry (not the Kee Berry), etc.
For Mewtwo's Final Smash, it transforms into Mega Mewtwo Y and then uses Psystrike.
In Pokémon GO, Psystrike is a Charged Attack that has been available on September 16, 2019.