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Scizor debuted in Battle Royal 151!, where Guzma used it during the Manalo Conference preliminary round, defeating a Kommo-o. It was one of the 16 Pokémon that remained standing by the end, allowing its Trainer to advance to the actual tournament.
In Battling Besties!, Scizor was used by Guzma to battle Ilima and his Kangaskhan during the first round of the competition. Despite Ilima Mega Evolving Kangaskhan, Scizor strategically defeated its opponent by using Kangaskhan's child as a shield, forcing the mother to hesitate. This created several attack opportunities, leading to her exhaustion and defeat, allowing Guzma to advance to the second round.
In Getting Down to The Ire!, Scizor was the first Pokémon Guzma used during his battle against Ash in the semifinals, where it went up against Torracat. After using U-turn, Scizor returned to its Poké Ball and switched with Golisopod due to it having a strong type disadvantage against Torracat. However, Golisopod later retreated from a Fire Blast by activating its Emergency ExitAbility and sent out Scizor without warning, leaving it with no time to dodge or counter the move. As a result, Scizor took a direct hit and was knocked out.
Scizor shares many traits with Guzma; it can be brutal and strategic, as seen during its battle with Ilima and Kangaskhan in Battling Besties!, where it carefully used Kangaskhan's own child against her by purposefully positioning itself between her and the child, forcing the Parent Pokémon to hesitate when attacking and allowing Scizor to gain the upper hand and ultimately secure the victory.
Aside from Golisopod, Scizor seems to be Guzma's most reliable Pokémon. This was evidenced in Getting Down to The Ire! when, after Golisopod used its Emergency Exit to force Scizor back out to take Torracat's Fire Blast in its place, Guzma was incensed since his plan for the battle was to rely on Scizor to secure the winning knockout, showing the faith he has on the Pincer Pokémon.