221

By regional Pokédex number, 221 may refer to:

• #221 Piloswine, in the National Pokédex
• #221 Omastar, in the New Pokédex
• #221 Porygon2, in the Johto Pokédex
• #221 Gligar, in the New Unova Pokédex
• #221 Pangoro, in the Alola Pokédex in Sun and Moon
• #221 Wimpod, in the Alola Pokédex in Ultra Sun and Ultra Moon
• #221 Lanturn, in the Galar Pokédex

By Browser number, 221 may refer to:

• R-221 Mismagius, in the Almia Browser
• R-221 Salamence, in the Oblivia Browser

In the Pokémon anime series, 221 may refer to:

• A Parent Trapped!, episode 221 of the original series

In the Pokémon games, 221 may refer to:

• Sinnoh Route 221, a route in Sinnoh

In the Pokémon manga, 221 may refer to:

• Going to Eleven with Loudred & Exploud II, round 221 in the Ruby & Sapphire arc of Pokémon Adventures