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Professor Oak's Laboratory, also called the Oak Pokémon Research Laboratory, is a Pokémon lab located in Pallet Town that is directed by Professor Samuel Oak and, in the anime, his assistant Tracey Sketchit. Its functions are to research Pokémon, unravel the mysteries of these creatures, and study their characteristics and behavior in a natural environment. Another important job is to take care of the Pokémon that belong to Pallet Town's trainers.

The lab has many different environments for the correct development of all kinds of Pokémon. They are areas of grass, sand, rocks and lakes to promote good interaction between the different types of creatures. The laboratory has the technology to keep Pokémon healthy, and to make the largest scientific investigations in the country.

Professor Oak's Laboratory appears in Pokémon Red, Blue, and Yellow, Pokémon Gold, Silver, and Crystal, and Pokémon FireRed and LeafGreen. In Generation I, it is where Oak gives the player their starter Pokémon and a Pokédex.

In the anime, the laboratory debuted in the first episode, Pokémon - I Choose You!, when Ash received his Pikachu. Since then, it has been seen in many episodes, mostly in the start and ending of a region adventure, but also in Pokémon Chronicles and in the movies. The building stands out in Pallet Town for its wind turbine, the three windows of the inner balcony, and for the four windows of the second floor. Every time Ash captures a Pokémon when he has six already with him, the new Pokémon is automatically transported here. Ash also has a habit of leaving all of his Pokémon besides Pikachu here each time he leaves for a new region, starting with Hoenn.

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