Pokémon Black and White
After defeating the Elite Four, this castle rises from the ground and attaches itself to the Pokémon League building. According to a Team Plasma Grunt, the castle was being secretly built for several years by overworking Pokémon that were taken away from other Trainers.
As the player enters the first floor, six of the Seven Sages attempt to stop him or her. However, the Gym Leaders of Unova (with the exception of Cilan, Chili, and Cress as Bianca was apparently unable to reach them in time) intercept the surprise attack, allowing the player to continue.
On the second floor, a member of the Shadow Triad directs the player to a room where two women await him or her, introducing themselves as Anthea and Concordia. Anthea heals the player's party and Concordia tells the player about N's childhood. A room on the third floor contains a PC that will allow the player to rearrange the party as well. In the same room, scientists mention that now, they could infiltrate the Pokémon Storage System to even release the Pokémon from Trainers' PC Boxes. Team Plasma Grunts are scattered about the other rooms of the building; however, unlike their other encounters, they will not fight, instead celebrating victory or thinking of saying goodbye to their Pokémon. One of these Grunts will allow the player to return to the Pokémon League.
N's room resides on the fourth floor. It is decorated in a childish manner, with cloud wallpaper and floor covering as well as there being many toys strewn about the area, many of which can be interacted with. Some of them show sign of recent usage (such as the train set) and some of which denote usage by Pokémon as well as humans, such as the skating ramp which upon inspection is covered in claw marks and scratches. There is a home basketball hoop installed on the west wall, before which lies a basketball with the word "Harmonia" inscribed on it—N and Ghetsis's surname.
Right before the final battle with N, the mascot of either Pokémon Black or Pokémon White emerges. The respective Legendary Pokémon can now be caught, and if there is space in the party, the Legendary Pokémon will be used in the battle against N, where it is also first in the party. Otherwise, it is possible to swap the Legendary Pokémon from the PC to the party.
During the battle with N, he uses the Legendary Pokémon opposite of the game's mascot.
After defeating N, the player must battle Ghetsis, who reveals that he was manipulating N and Team Plasma in order to achieve his own goals.
Once these events have taken place, the castle is no longer accessible, making the items inside inaccessible as well.
In Pokémon Black 2 and White 2
The ruins of N's Castle can be accessed from a large cavern that is located within Victory Road. However, the remnants of the castle can only be accessed after the player has entered the Hall of Fame.
After the player has entered the Hall of Fame, N's Zoroark stops blocking the path that leads to the ruins of N's Castle on Victory Road and lead the player there. After entering the castle, the player and N walk around the ruins that used to be N's Castle, including N's room and the castle's throne room. In the throne room, N asks the player to battle him and his ZekromB2/ReshiramW2. After the player defeats him, N reverts his dragon to its dormant state—the Dark StoneB2/Light StoneW2—and gives it to the player to summon ZekromB2/ReshiramW2 at Dragonspiral Tower to catch.
After catching ZekromB2/ReshiramW2, N appears in Nimbasa City near the Rondez-View Ferris Wheel every Friday. After a ride with him and having battled Kyurem in the Giant Chasm, he returns to his castle for a rematch with different Pokémon depending on the season.
In the main series
N's Castle was first seen in a flashback in The Name's N!. When Ash told N how he and his friends were trying to find Reshiram, N had a flashback of his youth, a moment when he had been at his castle, which, along with its surroundings, had been on fire. He saw Reshiram appearing before him, and kept looking at it as it flew away.
The Castle was also seen in a flashback in Secrets From Out of the Fog!, where a ceremony involving N and led by Ghetsis and the other Seven Sages was taking place, when suddenly Reshiram appeared, setting the castle ablaze with its Fire attacks, preventing the ceremony from being completed, much to Ghetsis's anger.
In the anime, the castle is described as a mansion and is less grand in appearance than it is in the games.
In Pokémon Generations
N's Castle in Pokémon Generations
N's Castle appeared in The Uprising. Like in Pokémon Black and White, it rose from the ground around the Pokémon League, with the Seven Sages standing at the tops of the rising towers. Iris started battling against the army of Team Plasma Grunts coming out of the castle, with the rest of Unova's Gym Leaders soon joining the fight.
N's Castle in Pocket Monsters BW: The Heroes of Fire and Thunder
In the Pokémon Adventures manga
N's Castle in Pokémon Adventures
N's Castle is Team Plasma's main base of operations. It debuted in Listening to Pokémon in N's flashback of his coronation as king of Team Plasma.
During Team Plasma's attack on the Pokémon League, Zinzolin summoned the castle via remote control. The castle then rose from the depths of the earth, surrounding the League building. Team Plasma Grunts emerged from the castle and surrounded the League viewers, while the Seven Sages and N watched from above as the chaos took place. N and Black had their final battle on top of the castle, which eventually moved to inside. White found her way in N's room after being teleported there by Hood Man, where she met Anthea and Concordia.
After Black successfully beat N, Ghetsis attacked him in order to silence him and keep the word of N's defeat from getting out. As Ghetsis had assembled a team of Pokémon specifically designed to counter Black's team, Black was initially at a disadvantage. However, after he figured out and that Ghetsis was using a Volcarona to power up his Pokémon, and had his Pokémon swap their opponents to ones more suitable for them, he was finally able to defeat Ghetsis. Afterwards, N flew away with Zekrom, and as Reshiram's counterpart was no longer present, the Vast White Pokémon started reverting back into its form as the Light Stone. Seizing the chance, Ghetsis pushed Black into Reshiram, causing him to be sucked into the Light Stone as well. Before White could grab the stone, it flew away into parts unknown.
In the Pocket Monsters BW: The Heroes of Fire and Thunder manga
N's Castle appeared in Clash! White Hero vs Black Hero. After successfully awakening Reshiram at the Relic Castle, Shin flew the Legendary Pokémon to N's Castle and started his battle against N and his Zekrom. Although Reshiram was unable to beat its counterpart, it was able to provide Shin's Emboar with enough firepower to allow its Flare Blitz to defeat Zekrom. After being defeated, N promised Shin to reconsider his ideology, before flying away with Zekrom.