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Route 758 was the location of the real-world PokéPark theme park, located in Nagoya, Japan.
There was a contest to name the street PokéPark was to be built in to give it a location in the Pokémon world. There were 2,203 entrants, and "Route 758" was the winner.
In Japanese, phone numbers are sometimes given as mnemonics derived from alternate pronunciations of the digits—for example, one such mnemonic for 262816 might be furo ni hairō. One possible mnemonic for 758 is nagoya, from nanatsu go yattsu, and it is possible this was the reason the name was chosen.